I have a question. Twitter is a kind of Microblogging. There are number of desktop clients for Microblogging, for example Thwirl or TweetDeck. Do you use Twitter or Microblogging, and what kind of desktop client do you use for it?
(lolcats photo is from Flickr user pinprick)
4 Lines of Code 
Nobody who reads this blog uses a Microblogging service? Come on..
twhirl is the best desktop client imo. It has a nice integration for several short URL services and a seamless integration of twitpic. Granted it does not look as nice as, say, Twitterific, but the feature set is great and through the Adobe AIR platform it runs on any OS that is supported by Adobe AIR.